Medication Overview
Prolia (denosumab) is an injectable prescription medication used primarily to treat osteoporosis in postmenopausal women who are at high risk for fractures, men with osteoporosis, individuals with bone loss due to hormone therapy for cancer, and certain cases of bone loss associated with long-term systemic glucocorticoid therapy. Prolia works by inhibiting a protein called RANK ligand, which plays a crucial role in bone resorption, helping to increase bone mass and reduce the risk of fractures.
Who Should Consider Prolia? Prolia is suitable for:
- Postmenopausal women and men at high risk for fractures due to osteoporosis.
- Individuals experiencing bone loss as a result of hormone therapy for cancer.
- Patients undergoing long-term systemic glucocorticoid therapy who have experienced significant bone loss.
How is Prolia Administered? Prolia is administered as a subcutaneous injection every six months. The injection is typically given by a healthcare professional in a clinical setting, such as a doctor’s office or clinic.
Important Information for Prolia Users:
- How to Use: Prolia injections are given twice a year. Ensure to keep appointments as scheduled to maintain effectiveness.
- Storage: Prolia should be stored in a refrigerator and should not be frozen. It is generally prepared and administered by healthcare professionals.
- Side Effects: Common side effects include back pain, pain in extremities, and high cholesterol levels. Serious side effects can include low calcium levels in the blood, infections, and jaw bone problems. Report any severe or unusual symptoms to your healthcare provider.
- Monitoring: Regular medical check-ups are recommended to monitor calcium levels, overall bone health, and any potential side effects.
Medication Warnings
- Hypocalcemia: Prolia may cause low blood calcium levels, so it is important to take calcium and vitamin D as recommended by your doctor.
- Infections: Prolia can impair the immune system, increasing the risk of serious infections. Report any signs of infection, such as fever or chills, to your doctor.
- Osteonecrosis of the Jaw: There is a risk of osteonecrosis of the jaw; maintain good oral hygiene and receive regular dental check-ups.
- Atypical Femoral Fractures: Patients should report any new or unusual thigh, hip, or groin pain as these may be early symptoms of a femoral fracture.
- Dermatological Reactions: Alert your healthcare provider if you experience severe skin reactions, including blisters or peeling skin.
Who Should and Shouldn’t Take Prolia?
- Suitable Candidates:
- Those at significant risk for bone fractures due to osteoporosis, hormonal therapy, or steroid use.
- Unsuitable Candidates:
- Individuals with hypocalcemia that is not adequately managed.
- Patients with severe kidney disease or on dialysis, as they may be more susceptible to serious side effects from low calcium levels.
- Those with a history of systemic infections or immune system disorders, unless closely monitored by a healthcare provider.
For more detailed information and personalized advice, consult your healthcare provider.
