Dupixent (dupilumab) is an injectable prescription medication used to treat moderate to severe eczema (atopic dermatitis), asthma, and chronic rhinosinusitis with nasal polyps. It is a monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13), which play key roles in the inflammatory response associated with these conditions.
Who Should Consider Dupixent?
Dupixent is appropriate for adults and adolescents who:
- Have moderate to severe atopic dermatitis that is not well controlled with topical treatments.
- Suffer from asthma that is inadequately controlled with inhalers or other medications, or for those who require additional therapy.
- Have chronic rhinosinusitis with nasal polyps, especially when other treatments haven’t been effective.
How is Dupixent Administered?
Dupixent is administered as a subcutaneous injection, usually every two weeks. The medication is typically given in the thigh, abdomen, or upper arm, and patients can self-administer after proper training from a healthcare professional using a pre-filled syringe or pen injector.
Important Information for Dupixent Users
- How to Use: Inject Dupixent as prescribed by your healthcare provider. Ensure to alternate injection sites to reduce irritation.
- Storage: Store Dupixent in the refrigerator, but allow it to reach room temperature before injecting.
- Side Effects: Common side effects include injection site reactions, eye problems (conjunctivitis), and cold sores. Contact your healthcare provider if you experience any severe or unexpected symptoms, such as vision changes.
- Monitoring: Regular follow-ups may be necessary to monitor the treatment’s effectiveness and manage any side effects.
Medication Warnings
- Allergic Reactions: Some patients may experience serious allergic reactions to Dupixent, including rash, fever, and swelling. Seek immediate medical attention if you notice any of these symptoms.
- Eye Problems: Dupixent has been associated with eye-related side effects, such as conjunctivitis or keratitis. Inform your healthcare provider if you experience eye pain, blurry vision, or redness.
- Parasitic Infections: Patients with parasitic infections (helminth infections) should have these infections treated before starting Dupixent, as it may impact the body’s ability to fight such infections.
Who Should and Shouldn’t Take Dupixent?
Suitable Candidates:
- Adults and adolescents with moderate to severe eczema who haven’t responded well to topical treatments.
- Individuals with asthma that is poorly controlled despite regular treatments.
- Those with chronic rhinosinusitis and nasal polyps who require additional therapy for symptom management.
Unsuitable Candidates:
- Patients with known allergies to dupilumab or any of the other components in Dupixent.
- Individuals with active parasitic infections, unless treated prior to using Dupixent.
- Pregnant or breastfeeding individuals should consult their healthcare provider before using Dupixent, as its safety in pregnancy and breastfeeding has not been fully established.
For more detailed information and personalized advice, consult your healthcare provider.
