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Medication Overview

Benlysta (belimumab) is an injectable prescription medication used to treat systemic lupus erythematosus (SLE) and lupus nephritis in adults. It functions by targeting and inhibiting a specific protein called B-lymphocyte stimulator (BLyS), which contributes to the abnormal B cell activity in lupus.

Who Should Consider Benlysta? Benlysta is appropriate for adults who:

Infections may weaken your immune system, elevating your risk of infections. Immediately report any signs of infection, such as feve

  • Have active systemic lupus erythematosus (SLE) despite receiving standard therapy.
  • Are diagnosed with lupus nephritis and require additional treatment to manage the disease.
  • Need a medication that specifically targets B-cell activity in lupus.

How is Benlysta Administered? Benlysta can be administered in two ways:

  • Intravenous (IV) Infusion: Administered by a healthcare professional in a clinical setting, typically every 2 to 4 weeks.
  • Subcutaneous Injection: Self-administered weekly using a pre-filled syringe or autoinjector. Your healthcare provider will instruct you on how to perform the injection under the skin of your abdomen or thigh.

Important Information for Benlysta Users:

  • How to Use: Follow your healthcare provider’s instructions for administering Benlysta, whether by infusion or injection.
  • Storage: Keep Benlysta refrigerated. If using a pre-filled syringe or autoinjector, allow it to reach room temperature before injecting.
  • Side Effects: Common side effects include nausea, diarrhea, fever, headaches, sore throats, and injection site reactions. Report any severe or unusual symptoms to your doctor.
  • Monitoring: Regular medical check-ups and blood tests are recommended to monitor your health and the medication’s effects.

Medication Warnings

  • Infections: Benlysta may weaken your immune system, elevating your risk of infections. Immediately report any signs of infection, such as fever, chills, or persistent cough, to your healthcare provider.
  • Mental Health: There is a risk of depression, mood changes, and suicidal thoughts. Alert your healthcare provider if you experience these symptoms.
  • Allergic Reactions: Seek immediate medical help if you experience symptoms like rash, itching, swelling, dizziness, or trouble breathing.
  • Infusion Reactions: Some individuals may experience reactions during or after an IV infusion, such as headaches, nausea, and low blood pressure. Inform your healthcare provider if these symptoms occur.
  • Cancer Risk: There is a potential increased risk of certain types of cancer. Discuss your medical history and risk factors with your healthcare provider.

Who Should and Shouldn’t Take Benlysta?

  • Suitable Candidates:
    • Adults with active SLE or lupus nephritis seeking specific B-cell targeted therapy.
  • Unsuitable Candidates:
    • Individuals with severe, active infections.
    • Patients with a history of hypersensitivity to belimumab or any of the excipients in the formulation.
    • Those with severe psychiatric conditions without proper medical supervision due to the risk of mental health side effects.